Geranylgeraniol-d5

Geranylgeraniol-d5 is the deuterium labeled Geranylgeraniol. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model[1][2][3][4].

174873-05-3

12352211

Isotope-Labeled Compounds; NF-κB

NF-κB; Others

COVID-19-immunoregulation

Inflammation/Immunology

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C([2H])([2H])[2H])=C/C([2H])([2H])O

C20H29D5O

295.51

[1]Saputra WD, et al. Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation. Int J Mol Sci. 2021 Sep 29;22 (19) :10543. |[2] Marcuzzi A, et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. Int J Mol Sci. 2016 Mar 11;17 (3) :365. |[3] Preece K, et al. A toxicological evaluation of geranylgeraniol. Regul Toxicol Pharmacol. 2021 Aug;124:104975. |[4] Giriwono PE, et al. Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. Eur J Nutr. 2013 Apr;52 (3) :1191-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W011474S/

Isotope-Labeled Compounds

No Development Reported