GFP-antilichaam

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.

5199

P27918

P27918

Human

This CFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-223 amino acids from the Central region of human CFP.

Unconjugated

Primary Antibodies

Immunology

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

51 kDa

Rabbit Ig

CFP

Properdin

Homo sapiens

Seitsonen, S., et al. Mol. Immunol. 47 (6) :1334-1336 (2010)

Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)

Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29 (7) :966-973 (2009)

Keslar, K., et al. Transplantation 86 (9) :1319-1321 (2008)

Properdin, Complement factor P, CFP, PFC

WB, Flow

464473

Liquid