GFR alpha 1 Antilichaam

GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα -1 recently. GFRα -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK) . Thus, GDNF, GFRα and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

2674

P56159

P56159

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Growth Factors, Neuroscience

GFR alpha 1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GFR alpha 1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

51 kDa

IgG

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

GFRA1

Cat. No. 1304 - Human Liver Tissue Lysate

Cat. No. 1305 - Human Kidney Tissue Lysate

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

GDNF family receptor alpha 1

Homo sapiens

Jing S, Wen D, Yu Y, et al. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell 1996; 85:1113-24.

Treanor JJS, Goodman L, Sauvage FD, et al. Characterization of a multicomponent receptor for GDNF. Nature 1996;82:80-83.

Sanicola M, Hession C, Worley D, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci. USA 1997; 94:6238-43.

Buj-Bello A, Adu J, Pinon LG, et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997; 387:721-4

GFR alpha 1 Antibody: GDNFR, RET1L, RETL1, TRNR1, GDNFRA, GFR-ALPHA-1, GDNF family receptor alpha-1, RET ligand 1, GDNF receptor alpha-1

ELISA, WB, IHC-P, IF

20141405

Liquid