GFR alpha 3 Antilichaam

GFR alpha 3 Antibody: Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα -1 and -2, a novel receptor in GFRα family was identified from human and mouse and designated GFRα -3. GFRα -3 binds persephin, thus, persephin, GFRα -3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

14587

O35118

NP_034410

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Growth Factors, Neuroscience

GFR alpha 3 Antibody is DEAE purified.

Cat. No. 1401 - Mouse Heart Tissue Lysate

1 mg/ml

GFR alpha 3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GFR alpha 3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Gfra3

Cat. No. 1404 - Mouse Liver Tissue Lysate

Glial cell line derived neurotrophic factor family receptor alpha 3

Mus musculus

Milbrandt J, de Sauvage FJ, Fahrner TJ, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 1998; 20:245-253.

Nomeclature Committee. Nomeclature of GPI-linked receptors for the GDNF ligand family. GFRa. Neuron 1997; 19:485.

Jing S, Yu Y, Fang M, et al. GFRα -2 and GFRα -3 are two new receptors for ligands of the DGNF family. J. Biol. Chem. 1997; 272:33111-7.

Baloh RH, Gorodinsky A, Golden JP, et al. GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 1998; 95:5801-6.

GFR alpha 3 Antibody: Y15110, GFRalpha3, GDNF family receptor alpha-3, GDNF receptor alpha-3

ELISA, WB, IHC-P, IF

160298126

Liquid