GHR Antilichaam

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

2690

P10912

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 26-260 of human GHR (NP_001229328.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Growth Factors, Signal Transduction

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 72kDa

IgG

WB: 1:500 - 1:2000

GHR

Mouse heart

Mouse kidney

Rat liver

Growth hormone receptor

Homo sapiens

GHBP, GHIP, growth hormone receptor, GH receptor, growth hormone binding protein, serum binding protein, somatotropin receptor

WB

Liquid