Ginnalin A

Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer[1].

76746-56-0

Acertannin

12352005

Heme Oxygenase (HO) ; Keap1-Nrf2; p62

Autophagy; Metabolic Enzyme/Protease; NF-κB

Cancer

O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@@H]2[C@@H](O)[C@H](O)[C@@H](COC(=O)C3=CC(O)=C(O)C(O)=C3)OC2

C20H20O13

468.37

[1]Bi W, et al. Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. Food Funct. 2018 May 23;9 (5) :2809-2819.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N17603/

Natural Products

No Development Reported

HO-1