GIT2 Antilichaam

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

9815

Q14161

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

Affinity purification

A-431

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 84kDa

IgG

WB: 1:200 - 1:2000

GIT2

LO2

Jurkat

HeLa

GIT ArfGAP 2

Homo sapiens

CAT-2, CAT2, PKL, ARF GTPase-activating protein GIT2, ARF GAP GIT2, G protein-coupled receptor kinase interacting ArfGAP 2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, Paxillin kinase linker, cool-associated, tyrosine phosphorylated protein 2, cool-interacting tyrosine-phosphorylated protein 2

WB

Liquid