GITR-eiwit (Zijn & AVI-tag), gebiotinyleerd

GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

AITR Protein; CD357 Protein; ENERGEN Protein; GITR Protein; GITR-D Protein; UNQ319/PRO364 Protein

NP_683700.1

Human

Human

His-/AVI-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 95 % as determined by SDS-PAGE.

Immobilized Human GITRL mFc at 2 μg/mL (100 μL/well) can bind Human GITR, Biotinylated, the EC50 is 15-90 ng/mL.

162

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

29 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells