GITR / TNFRSF18 Proteïne (hFc dag)

GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

AITR Protein; Gitr Protein; Tnfrsf18 Protein

Q9Y5U5-1

Human

Human

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Data not available

377

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

96 kDa and 45 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells