GJB2 Antilichaam

The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1) . Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2) . Other mutations in this gene have also been linked to a wide array of skin diseases (3) .

2706

P29033

NP_003995

Human

Unconjugated

Primary Antibodies

Homeostasis

GJB2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1320 - Human Colon Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%), Sheep: (88%), Bovine: (88%), Chicken: (82%)

GJB2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GJB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GJB2 antibody is human specific.

GJB2

Gap junction protein, beta 2, 26kDa

Homo sapiens

Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions – An update. FEBS Lett. 2014; 588:1186-92.

Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.

Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.

Gap junction beta-2 protein, connexin 26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK

ELISA, WB

42558283

Liquid