GK730
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
GK730 is a potent and selective SARS-CoV-2 main protease inhibitor with an IC50 of 5.75 nM. GK730 does not inhibit cathepsin B, while exhibits weak inhibition of cathepsin L (IC50 = 11 μM) . GK730 can simultaneously block the replication of the virus and the entry pathways for variants such as Omicron into cells. GK730 demonstrates an EC50 value of 5.70 μM against a wild-type SARS-CoV-2 strain in Vero E6 cells and CC50 value greater than 100 μM. GK730 can be used for the research of COVID-19[1].
12352005
SARS-CoV
Anti-infection
Infection
O=C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C[C@@H]1CCNC1=O)C(C2=NC(C(OC)=O)=CS2)=O)=O)=O)OCC3=CC=CC=C3
C31H41N5O8S
643.75
[1]Theodoropoulou MA, et al. Thiazolyl 4-carboxylate ketone as a new warhead for a highly potent SARS-CoV-2 main protease inhibitor. Eur J Med Chem. 2026 Feb 5;303:118436.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-180229/
Reference compound1
No Development Reported
Beschrijving
GK730 is a potent and selective SARS-CoV-2 main protease inhibitor with an IC50 of 5.75 nM. GK730 does not inhibit cathepsin B, while exhibits weak inhibition o
Specificaties
Recent bekeken producten
DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 1 µm
DCFG-L007
1 mL
DiagPoly™ Carboxyl Polystyrene Particles, 1.0 µm
DNM-F029
10 mL
DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 0.2 µm
DCFG-L004
1 mL
Optical EtBr filter, 610 nm for SmartView Pro Imager System, 1100 & 2100 series (for UV)
UVCI-1100-EB
1 Unit
AGPAT4 Antibody
MBS7124622-01
0.05 mL
H&E Mount, Permanent Mountindg media for coverslipping H&E stains from water,
NB315
125 mL
SCD polyclonal antibody
GTR18043932-01
50 μL
(KO Validated) SUMO1 Polyclonal Antibody
E-AB-92410-01
60 µL
Recent gezochte producten
DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 1 µm
DCFG-L007
1 mL
DiagPoly™ Carboxyl Polystyrene Particles, 1.0 µm
DNM-F029
10 mL
DiagPoly™ Carboxyl Fluorescent Polystyrene Particles, Green, 0.2 µm
DCFG-L004
1 mL
M-90-422 AF Systems Consumables
131576
Box of 180 Label(s)
Consumable Pack M996030
WAT1096
1 Each
Consumable Pack M996039
WAT1108
1 Each
Consumable Pack M996034
WAT1106
1 Each
Consumable Pack M996038
WAT1102
1 Each