GLIS2 Antilichaam

GLIS2, also known as neuronal Krueppel-like, is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family (1) . GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation (1,2) . GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Mutations of GLIS2 have been suggested to be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis (3,4) .

84662

Q9BZE0

NP_115964

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Neuroscience

GLIS2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

GLIS2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GLIS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GLIS2 antibody is human, mouse and rat reactive.

GLIS2

GLIS family zinc finger 2

Homo sapiens

Vasanth S, ZeRuth G, Kang HS, et al. Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2) . J. Biol. Chem. 2011; 286:4749-59.

Hosking CR, Ulloa F, Hogan C, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Biol. Cell 2007; 18:1918-27.

Kim YS, Kang HS, Herbert R, et al. Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Mol. Cell Biol. 2008; 28:2358-67.

Attanasio M, Uhlenhaut NH, Sousa VH, et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat. Genet. 2007; 39:1018-24.

GLIS family zinc finger 2, GLI-similar 2, neuronal krueppel-like protein, NKL, NPHP7

ELISA, WB, IHC-P

110431364

Liquid