GLP-antilichaam [1B7B4]

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.

79813

Q9H9B1

Q9H9B1

Human

Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3) .

1B7B4

Unconjugated

Primary Antibodies

Neuroscience

Antibody is purified by protein A affinity chromatography.

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

GLP monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

EHMT1

Euchromatic histone-lysine N-methyltransferase 1

Homo sapiens

Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27.

Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38 (5-6) :845-859.

Andrew Young Adv Pharmacol. 2005;52:151-71.

EUHMTASE1, GLP, KIAA1876, KMT1D, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, GLP1, FP13812, EUHMTASE1, bA188C12.1, RP11-188C12.1

ELISA, WB

325511404