Glucosamine-13C6

Glucosamine-13C6 (D-Glucosamine-13C6) is 13C labeled Glucosamine. Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

D-Glucosamine-13C6; Chitosamine-13C6

12352211

Autophagy; CFTR; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; Others

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

[13C][13C](O)[13C](O)[13C](O)[13C](N)[13C]

C78H5NO3

1003.88

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45 (4 Suppl) :S12-7.|[3]Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38 (1) :212-9.|[4]Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44 (5) :1699-706.|[5]Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl) . 2013 Nov;91 (11) :1273-84.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1125S/

Isotope-Labeled Compounds

No Development Reported