Glutathionperoxidase 2 (GPX2) (NM 002083) Humaan Recombinant eiwit

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

Purified recombinant protein of Human glutathione peroxidase 2 (gastrointestinal) (GPX2), Val63-Ala151, with N-terminal His-ABP tag, expressed in E. coli, 50ug

GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI

2877

P18283

NM_002083

14q23.3

E. coli

N-His-ABP

Arachidonic acid metabolism, Glutathione metabolism

Arachidonic acid metabolism, Glutathione metabolism

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome

25.2 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

GPX2

Human

NP_002074

https://www.ncbi.nlm.nih.gov/gene/2877

https://www.uniprot.org/uniprot/P18283

https://www.ncbi.nlm.nih.gov/nuccore/NM_002083

https://www.ncbi.nlm.nih.gov/nuccore/NP_002074