Glypican-3/GPC3, Cynomolgus (HEK293, Fc)

GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development[1][2][3]. Glypican-3/GPC3 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-hFc labeled tag.

Glypican-3/GPC3 Protein, Cynomolgus (HEK293, Fc), Cynomolgus, HEK293

12352202

102137748 (Gene_ID) XP_005594665.1 (Q25-H559) (Accession)

Approximately 40 kDa

[1]Midorikawa Y, et al. Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer. 2003 Feb 10;103 (4) :455-65.|[2]Shih TC, et al. Glypican-3: A molecular marker for the detection and treatment of hepatocellular carcinoma. Liver Res. 2020 Dec;4 (4) :168-172.|[3]Zhou F, et al. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment. Med Res Rev. 2018 Mar;38 (2) :741-767.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins