GMEB2 Polyklonale Antilichaam, Biotinevervoeging

GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.

GMEB2; DNA binding protein p79P; DNA-binding protein p79P; Glucocorticoid modulatory element binding protein 2; Glucocorticoid modulatory element-binding protein 2; GMEB 2; GMEB-2; Gmeb2; GMEB2_HUMAN; KIAA1269; P79P; Parvovirus initiation factor p79; P p79; P79; RP4 663D7.1.

26205

Cytoplasm, Nucleus

Mouse

101-200/530

GMEB2

Biotin

KLH conjugated synthetic peptide derived from human GMEB2

WB, ELISA, IHC-P, IHC-F

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

26205

Human, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit