GNA12 Proteïne, Muis, Recombinant (His & Myc)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) . GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Ice Packs
-20°C
Beschrijving
GNA12 Proteïne, Muis, Recombinant (His & Myc) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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