GnRH-antagonist 3

GnRH antagonist 3 (Compound 11) is a GnRH antagonist with an IC50 of 7 nM. GnRH antagonist 3 can be used in the research of hormone-dependent diseases[1].

292141-31-2

12352209

H302-H315-H319-H335

GnRH Receptor

GPCR/G Protein

Metabolism-protein/nucleotide metabolism

Metabolic Disease

ClC(C=C1)=CC=C1C[C@@H](NC([C@H](NC(C)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)C(N[C@H](CC4=CC=CC=N4)C(NCC(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@H](C)C(N)=O)=O)=O)=O)=O)=O

C48H59ClN12O8

967.51

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Yahalom D, et al. Design and synthesis of potent hexapeptide and heptapeptide gonadotropin-releasing hormone antagonists by truncation of a decapeptide analogue sequence. J Med Chem. 2000 Jul 27;43 (15) :2831-6.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P5897/

Peptides

No Development Reported