GNRHR Antilichaam

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) . Defects in this gene are a cause of hypogonadotropic hypogonadism (HH) . Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

2798

P30968

Human, Mouse

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human GNRHR (NP_000397.1) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 38kDa

IgG

WB: 1:500 - 1:2000

GNRHR

Mouse brain

Gonadotropin-releasing hormone receptor

Homo sapiens

Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR

WB

Liquid