GOLGIN97 Antilichaam

GOLGIN97 was initially isolated as a Golgi complex autoantigen associated with Sjogren's syndrome, a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands (1,2) . GOLGIN97 plays a role as a tethering molecule in endosome to the trans-Golgi network (TGN) retrograde traffic (3) . FIP1/RCP binding to GOLGIN97 is required for tethering and fusion of recycling endosome retrograde transport vesicles to the TGN (4) .

2800

Q92805

NP_002068

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Immunology

GOLGIN97 antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

GOLGIN97 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GOLGIN97 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Heavily post-translationally modifed, multiple independent GOLGIN97 antibodies show bands at ~120kDa

IgG

GOLGIN97 antibody is human, mouse and rat reactive. At least two isoforms of GOLGIN97 are known to exist; this antibody will detect only the longer isoform. GOLGIN97 antibody is predicted to not cross-react with other GOLGIN family proteins.

GOLGA1

Golgin A1

Homo sapiens

Griffith KJ, Chan EK, Lung CC, et al. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome. Arthritis Rheum. 1997; 40:1693-702.

Borchers AT, Naguwa SM, Keen CL, et al. Immunopathogenesis of Sjogren's syndrome. Clin. Rev. Allergy Immunol. 2003; 25:89-104.

Lu L, Tai G, and Hong W. Autoantigen Golgin-97, and effector of ARL1 GTPase, participates in traffic from the endosome to the trans-Golgi network. Mol. Biol. Cell 2004; 15:4426-43.

Jing J, Junutula JR, Wu C, et al. FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Mol. Biol. Cell 2010; 21:3041-53.

Golgin subfamily A member 1, GOLGA1, GOLGIN A1, GOLGIN-97

ELISA, WB, IHC-P, IF

4504063

Liquid