Gonyaustoxin III

Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease[1][2].

60537-65-7

GTX-III

12352005

H300+H310

Sodium Channel

Membrane Transporter/Ion Channel

Cancer; Neurological Disease

OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@@H]1OS(=O)(O)=O)N)COC(N)=O)O

C10H17N7O8S

395.35

P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501

[1]Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9 (1) :57-65.|[2]Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+) -Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58 (6) :1689-1693.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W343059/

Reference compound2

No Development Reported