Gp120 Antilichaam

Gp120 Antibody: Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

155971

Q6BBS3

AAA80623

Virus

Unconjugated

Primary Antibodies

Infectious Disease

Gp120 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Gp120 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Gp120 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Gp120 antibody can be used for detection of gp120 by Western blot at 1 μ g/mL.

Env

Envelope glycoprotein

Human immunodeficiency virus 1

Pinter A. Roles of HIV-1 Env variable regions in viral neutralization and vaccine development. Curr. HIV Res.2007; 5:542-53.

Alkhatib G and Berger EA. HIV coreceptors: from discovery and designation to new paradigms and promise. Eur. J. Med. Res.2007; 12:375-84.

Gp120 Antibody: Envelope glycoprotein gp160

ELISA, WB

924676

Liquid