GPI Antilichaam

GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

2821

P06744

P06744

Human, Mouse

This GPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-473 amino acids from the C-terminal region of human GPI.

Unconjugated

Primary Antibodies

Cancer, Immunology, Obesity, Neuroscience, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Predicted species reactivity based on immunogen sequence: Monkey

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

63 kDa

Rabbit Ig

GPI

Glucose-6-phosphate isomerase

Homo sapiens

Shih, W.L., et al. Cancer Lett. 290 (2) :223-237 (2010)

Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

Araki, K., et al. J. Biol. Chem. 284 (47) :32305-32311 (2009)

Tsutsumi, S., et al. Int. J. Oncol. 35 (5) :1117-1121 (2009)

Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Sperm antigen 36, SA-36, GPI

WB, Flow

17380385

Liquid