GPR103 Polyklonale Antilichaam, PE Vervoeging

G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation) . GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR103 is a 455-amino acid protein with highest expression in the brain, retina, trigeminal ganglion, hypothalamus and vestibular nucleus. In peripheral tissues, GPR103 is expressed only in the heart, kidney and testis. GPR103 may regulate adrenal function. A hypothalamic neuropeptide of the RFamide family (26RFa) acts as an endogenous ligand for GPR103.

AQ27; G protein coupled receptor 103; G-protein coupled receptor 103; G protein-coupled receptor 103; Orexigenic neuropeptide QRFP receptor; Pyroglutamylated RFamide peptide receptor; QRFP receptor; QRFPR; SP9155; QRFPR_HUMAN; GPCR GPR103.

84109

Cell membrane

Human

151-250/431

GPR103

PE

KLH conjugated synthetic peptide derived from human G protein coupled receptor 103

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

84109

Mouse, Rat, Sheep, Horse, Rabbit