GPR3 Antilichaam

GPR3 Antibody: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Abeta in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.

2827

P46089

P46089

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

GPR3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

GPR3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GPR3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GPR3

Cat. No. 10-901 - Human Spleen Tissue Slide

G protein-coupled receptor 3

Homo sapiens

Marchesse A, Docherty JM, Nguyen T, et al. Cloning of human genes encoding novel G protein-coupled receptors. Genomics1994; 23:609-18.

Eggerickx D, Denef JF, Labbe O, et al. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem. J.1995; 309:837-43.

Thathiah A, Spittaels K, Hoffmann M, et al. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science2009; 323:946-951.

Blacker D, Bertram L, Saunder AJ, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum. Mol. Genet.2003; 12:23-32.

GPR3 Antibody: ACCA, ACCA, G-protein coupled receptor 3, ACCA orphan receptor

ELISA, WB, IHC-P, IF

1170006

Liquid