GPRASP1 Antilichaam

The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2) . GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2) . Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3) .

9737

Q5JY77

NP_001171656

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

GPRASP1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

GPRASP1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GPRASP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.

GPRASP1

G protein-coupled receptor associated sorting protein 1

Homo sapiens

Simonin F, Karcher P, Boeuf JJ, et al. Identification of a novel family of G protein-coupled receptor associated proteins. J. Neurochem. 2004; 89:766-75.

Moser E, Kargl J, Whistler JL, et al. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology 2010; 86:22-9.

Tuszynski GP, Rothman VL, Zheng X, et al. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. Exp. Mol. Pathol. 2011; 91:608-13.

G-protein coupled receptor-associated sorting protein 1, GASP, GASP-1, GASP1

ELISA, WB, IHC-P, IF

296080706

Liquid