GpTx-1 (TFA)

GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 TFA demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively[1].

12352209

Sodium Channel

Membrane Transporter/Ion Channel

Neurological Disease

99.56

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C176H271N53O45S7.xC2HF3O2

4073.82 (free base)

[1]Murray JK, et al. Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na (V) 1.7 sodium channel. J Med Chem. 2015 Mar 12;58 (5) :2299-314.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P1681A/GpTx-1-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported

Nav1.3; Nav1.4; Nav1.5; Nav1.7; Nav1.8