GPX2 Antilichaam

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

2877

P18283

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human GPX2 (NP_002074.2) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 21kDa

IgG

GPX2

HT-29

Mouse stomach

Rat small intestine

Glutathione peroxidase 2 (gastrointestinal)

Homo sapiens

GPX2, glutathione peroxidase 2 (gastrointestinal), HGNC:4554, GI-GPx, GSHPX-GI, gastrointestinal glutathione peroxidase 2, GPRP, GPx-2, GPRP-2, GPx-GI, GSHPx-2

WB, IHC

Liquid