GR-4991W93
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
GR-4991W93 is an orally active partial agonist against 5HT1B/1D receptor, with pIC50 values of 6.95 and 7.80 against 5HT1B and 5HT1D, respectively. GR-4991W93 demonstrates potent inhibition of electrically evoked plasma extravasation in the guinea pig. GR-4991W93 can be used for migraine research[1].
171549-56-7
12352005
5-HT Receptor
GPCR/G Protein; Neuronal Signaling
Neuroscience-Neuromodulation
Neurological Disease
CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32
C18H23N3O2
313.39
[1]Jandu KS, et al. Discovery of 4-[3- (trans-3-dimethylaminocyclobutyl) -1H-indol-5-ylmethyl]- (4S) -oxazolidin-2-one (4991W93), a 5HT (1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44 (5) :681-93.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19252/
Reference compound1
Phase 2
5-HT1 Receptor
Beschrijving
GR-4991W93 is an orally active partial agonist against 5HT1B/1D receptor, with pIC50 values of 6.95 and 7.80 against 5HT1B and 5HT1D, respectively. GR-4991W93 d
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