Granzyme B Polyklonale Antilichaam, AbBy FluorTM 488 Vervoeging

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; Granzyme B; C11; CTLA-1; Cathepsin G-like 1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; T-cell serine protease 1-3E; GZMB; GRB, Granzyme B, Granzyme H

3002

P10144

Cytoplasm

Human

21-130/247

Granzyme B

AbBy Fluor™ 488

KLH conjugated synthetic peptide derived from human GZMB

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

499nm/519nm

1µg/µl

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specific towards Granzyme B and Granzyme H

3002

Mouse, Rat, Cow, Pig