Granzyme B Recombinant eiwit

Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant murine Granzyme B is a glycosylated 227 amino acid protein, comprising the mature active portion of the murine Granzyme B precursor. The apparent molecular weight is 28.9 kDa by mass spectrometry.

14939

P04187

NP_038570.1

Recombinant Proteins

Baculovirus

Room Temp

The lyophilized Granzyme B recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Granzyme B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Granzyme B recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Granzyme B

Mus musculus

GZB, CCP1, Ctla1, Ctla-1, AI553453, CCP-1/C11, CTLA-1

Murine

7305123

Lyophilized