Grapiprant
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
Unconjugated
Off-white solid
-20°C
Beschrijving
Grapiprant Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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