Gravichinon
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research[1].
1383995-51-4
12352211
Checkpoint Kinase (Chk) ; Reactive Oxygen Species (ROS)
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Cancer
COC(/C=C/C1(C=CC(C=C1)=O)O)=O
C10H10O4
194.18
[1]Fási L, et al. Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. J Med Chem. 2019 Feb 14;62 (3) :1657-1668.
Room temperature
Reference compound1
No Development Reported
Beschrijving
Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of byp
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