GRB 14 Polyklonale Antilichaam

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14

2888

Q14449

Cytoplasm, Cell membrane

Human

221-320/540

GRB 14

Unconjugated

KLH conjugated synthetic peptide derived from human GRB 14

ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

1µg/µl

ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence.

2888

Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit