GRB 14 Polyklonale Antilichaam, PE Vervoeging

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14

2888

Q14449

Cytoplasm, Cell membrane

Human

221-320/540

GRB 14

PE

KLH conjugated synthetic peptide derived from human GRB 14

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence.

2888

Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit