GRB10 Antilichaam

GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.

2887

Q13322

NP_005302

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

GRB10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%)

GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GRB10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.

GRB10

Growth factor receptor-bound protein 10

Homo sapiens

Morrione A. Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review) . Int. J. Mol. Med. 2000; 5:151-4.

Liu F and Roth RA. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc. Natl. Acad. Sci. USA 1995; 92:10287-91.

Wick KR, Werner ED, Langlais P, et al. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS) -phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J. Biol. Chem. 2003; 278:8460-7.

Hu ZQ, Zhang JY, Ji CN, et al. Grb10 interacts with Bim L and inhibits apoptosis. Mol. Biol. Rep. 2010; 37:3547-52.

GRB10 Antibody: RSS, IRBP, MEG1, GRB-IR, Grb-10, GRBIR, KIAA0207, Growth factor receptor-bound protein 10, GRB10 adapter protein

ELISA, WB, IF

48762679

Liquid