Gremlin-1 Recombinant eiwit

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.

26585

O60565

NP_001178251.1

Recombinant Proteins

CHO cells

Signal Transduction

Greater than 90% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized Gremlin-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Gremlin 1, DAN family BMP antagonist

Homo sapiens

DRM, HMPS, PIG2, CRAC1, DAND2, IHG-2, GREMLIN, CKTSF1B1, DRM, Gremlin-1, Cell proliferation-inducing gene 2 protein

Human

300797307

Lyophilized