GRIA2 Antilichaam

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca (2+) . Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

2891

P42262

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 25-230 of human GRIA2 (NP_001077088.1) .

Unconjugated

Primary Antibodies

Neuroscience

Affinity purification

SH-SY5Y

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

GRIA2

HL-60

Mouse liver

Mouse brain

Mouse pancreas

Rat brain

Glutamate receptor, ionotropic, AMPA 2

Homo sapiens

GRIA2, GLUR2, GLURB, GluA2, HBGR2, GluR-K2

WB, IF

Liquid