GRIA4 Antilichaam

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

2893

P48058

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 254-433 of human GRIA4 (NP_001070712.1) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

SH-SY5Y

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 101kDa

IgG

WB: 1:1000 - 1:4000

GRIA4

B cells

Mouse brain

Mouse liver

Mouse kidney

Mouse spinal cord

Glutamate receptor, ionotropic, AMPA 4

Homo sapiens

GRIA4, glutamate receptor, ionotrophic, AMPA 4, GLUR4, GLUR4C, GLURD, AMPA-selective glutamate receptor 4

WB

Liquid