Grik1 Antilichaam

Grik1 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.

2897

P39086

P39086

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Grik1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Grik1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Grik1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GRIK1

Cat. No. 10-301 - Human Brain Tissue Slide

Glutamate receptor, ionotropic, kainate 1

Homo sapiens

Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.

Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.

Bureau I, Dieudonne S, Coussen F, et al. Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J. Neurosci.1999; 19:653-63.

Christensen JK, Paternain AV, Selak S, et al. A mosaic of functional kainate receptors in hippocampal interneurons. J. Neurosci.2004; 24:8986-93.

Grik1 Antibody: EAA3, EEA3, GLR5, GLUR5, GluK1, Glutamate receptor ionotropic, kainate 1, Excitatory amino acid receptor 3

ELISA, WB, IHC-P, IF

729597

Liquid