Grik2 Antilichaam

Grik2 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.

2898

Q13002

Q13002

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Grik2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Grik2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GRIK2

Glutamate receptor, ionotropic, kainate 2

Homo sapiens

Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.

Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.

Paschen W, Blackstone CD, Huganir RL, et al. Human GluR6 kainate receptor (GRIK2) : molecular cloning, expression, polymorphism, and chromosomal assignment. Genomics1994; 20:435-40.

Motazacker MM, Rost BR, Hucho T, et al. A defect in the ionotrophic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet.2007; 81:792-8.

Grik2 Antibody: EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2, Glutamate receptor ionotropic, kainate 2, Excitatory amino acid receptor 4

ELISA, WB

2492627

Liquid