Grik4 Antilichaam

Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs) : GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.

2900

Q16099

Q16099

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Grik4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Grik4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Grik4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

GRIK4

Cat. No. 10-301 - Human Brain Tissue Slide

Glutamate receptor, ionotropic, kainate 4

Homo sapiens

Tanaka K. Functions of glutamate transporters in the brain. Neurosci. Res.2000; 37:15-9.

Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.

Mayer ML. GRIK4 and the Kainate Receptor. Am. J. Psychiatry2007; 164:1148.

Pickard BS, Malloy MP, Christoforou A, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry2006; 11:847-57.

Grik4 Antibody: KA1, EAA1, GRIK, GluK4, Glutamate receptor ionotropic, kainate 4, Excitatory amino acid receptor 1

ELISA, WB, IHC-P, IF

209572625

Liquid