Grik5 Antilichaam

Grik5 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1) . Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

2901

Q16478

NP_002079

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

Grik5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Grik5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Grik5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This Grik5 antibody does not cross-react with Grik4.

GRIK5

Cat. No. 10-301 - Human Brain Tissue Slide

Glutamate receptor, ionotropic, kainate 5

Homo sapiens

Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.

Herb A, Burnashev N, Werner P, et al. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron1992; 8:775-85.

Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.

Nasu-Nishimura Y, Hurtado D, Braud S, et al. Tification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. J. Neurosci.2006; 26:7014-21.

Grik5 Antibody: KA2, EAA2, GRIK2, GluK5, Glutamate receptor ionotropic, kainate 5, Excitatory amino acid receptor 2

ELISA, WB, IHC-P, IF

29029597

Liquid