GRIN2B (fosfo Ser1303) Antilichaam

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B) . The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

2904

Q13224

NP_000825.2

Human, Mouse, Rat

GRIN2B (phospho Ser1303) antibody was raised against a peptide sequence around phosphorylation site of Serine 1303 (Q-H-S (p) -Y-D) derived from Human GRIN2B.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

170 kDa

IgG

The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.

Western Blot: 1:500~1:1000

GRIN2B

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Homo sapiens

Adams S.L., Biochim. Biophys. Acta 1260:105-108 (1995) .

Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816 (1996) .

Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.

GRIN2B, NMDE2, NME2, NR2B, NR3

WB

4504127

Liquid