GRINA Antilichaam

GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein) . They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.

2907

Q7Z429

NP_001009184

Human

Unconjugated

Primary Antibodies

Apoptosis

GRINA Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%), Bovine: (83%)

GRINA Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GRINA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 41 kDa

IgG

GRINA antibody is predicted to not cross-react with other members of the TMBIM family.

GRINA

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)

Homo sapiens

Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.

Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.

Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.

GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit

ELISA, WB

57165375

Liquid