GRK6 Antilichaam

The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2) . Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1) . GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4) . GRK6 may also play a role in immune system function (5) .

2870

P43250

NP_001004106

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

GRK6 antibody is affinity chromatography purified via peptide column.

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

1 mg/mL

GRK6 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

GRK6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.

GRK6

Cat. No. 11-801 - Human Small Intestine Tissue Slide

G protein-coupled receptor kinase 6

Homo sapiens

Inglese J, Freedman NJ, Koch WJ, et al. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 1993; 268:23735-8.

Raghuwanshi SK, Smith N, Rivers EJ, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J. Immunol. 2013; 190:5329-36.

Benovic JL and Gomez J. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J. Biol. Chem. 1993; 268:19521-7.

Chen M, Philipp M, Wang J, et al. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J. Biol. Chem. 2009; 284:35040-8.

GRK6 Antibody: GPRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6

ELISA, WB, IHC-P, IF

51896039

Liquid