GRM1 Antilichaam

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

2911

Q13255

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 920-1140 of human GRM1 (NP_000829.2) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

HL-60

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 132kDa

IgG

WB: 1:500 - 1:2000

GRM1

MCF7

Mouse brain

Rat brain

Metabotropic glutamate receptor 1

Homo sapiens

Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1

WB

Liquid