GRM2 Antilichaam

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

2912

Q14416

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 410-540 of human GRM2 (NP_000830.2) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

WB: 1:1000 - 1:2000

GRM2

HeLa

HepG2

Mouse liver

Mouse kidney

Glutamate receptor, metabotropic 2

Homo sapiens

GRM2, MGLUR2, mGlu2, GPRC1B, glutamate receptor, metabotropic 2, glutamate receptor homolog, glutamate metabotropic receptor 2, GLUR2

WB

Liquid