GRN Antilichaam - middengebied HRP (ARP54642_P050-HRP)

Granulin

GEP, GP88, PEPI, PGRN, CLN11, PCDGF

2896

P28799-2

Human, Horse

The immunogen is a synthetic peptide directed towards the middle region of Human GRN

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

OTX1; HOXA1; DLX2; SGTA; KRTAP26-1; KRTAP10-7; CCDC33; ARFGAP1; FANCL; NLK; GLRX3; EED; HECW2; Hk3; RPS6KA1; NPM1; POT1; FRAT1; YY1; TGM2; RAC1; PRKAB2; PIK3R2; SMAD9; KRT18; CRY1; CFTR; CCNG1; FBXO6; GFI1B; ATN1; CDK2; CRKL; VHL; SIRT3; ATXN7; CACNA1A; C

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity purified

0.5 mg/ml

Horse: 86%; Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Wet Ice

438

GRN

GRN

Rabbit

Granulins

QAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQAL